Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
gptkb:cancer
developmental disorders |
| gptkbp:discoveredIn |
1982
|
| gptkbp:encodes |
gptkb:Wnt_proteins
|
| gptkbp:example |
gptkb:WNT1
gptkb:WNT10B gptkb:WNT2 gptkb:WNT3 gptkb:WNT4 gptkb:WNT5A gptkb:WNT7A gptkb:WNT8A |
| gptkbp:foundIn |
animals
|
| https://www.w3.org/2000/01/rdf-schema#label |
WNT genes
|
| gptkbp:involvedIn |
gptkb:Wnt_signaling_pathway
|
| gptkbp:locatedOnChromosome |
various chromosomes in humans
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:tetra-amelia_syndrome gptkb:bone colorectal cancer |
| gptkbp:namedAfter |
Wingless (Drosophila) and Int-1 (mouse)
|
| gptkbp:numberOfMembers |
19 in humans
|
| gptkbp:orthologIn |
invertebrates
vertebrates |
| gptkbp:pathway |
canonical (β-catenin dependent)
non-canonical (β-catenin independent) |
| gptkbp:proteinProductType |
secreted glycoprotein
|
| gptkbp:recipient |
gptkb:Frizzled_family
|
| gptkbp:regulates |
apoptosis
cell proliferation embryonic development angiogenesis cell migration immune response axis patterning bone formation cell fate determination neurogenesis organogenesis stem cell maintenance cell polarity cell adhesion myogenesis adipogenesis hair follicle development limb development synapse formation |
| gptkbp:bfsParent |
gptkb:Wnt_ligands
|
| gptkbp:bfsLayer |
7
|