|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:INT1
gptkb:Proto-oncogene_Wnt-1
|
|
gptkbp:associatedWith
|
osteogenesis imperfecta
early-onset osteoporosis
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
embryonic development
|
|
gptkbp:conservedIn
|
vertebrates
|
|
gptkbp:discoveredBy
|
gptkb:Harald_Varmus
1982
|
|
gptkbp:encodedBy
|
gptkb:WNT1_gene
|
|
gptkbp:Entrez_Gene_ID
|
7471
ENSG00000125084
|
|
gptkbp:expressedIn
|
brain
embryonic tissues
|
|
gptkbp:function
|
developmental processes
signaling protein
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_Molecular_Function
|
signaling receptor binding
|
|
gptkbp:HGNC_ID
|
12782
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
WNT1 (human)
|
|
gptkbp:interactsWith
|
gptkb:Frizzled_receptors
gptkb:LRP5/6
|
|
gptkbp:length
|
370
|
|
gptkbp:locatedOnChromosome
|
12q13.12
chromosome 12q13
|
|
gptkbp:location
|
secreted
|
|
gptkbp:molecularWeight
|
39 kDa
|
|
gptkbp:mutationAssociatedWith
|
skeletal dysplasia
bone fragility
|
|
gptkbp:OMIM
|
164820
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Wnt1_(mouse)
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:7A1V
|
|
gptkbp:postTranslationalModification
|
palmitoylation
glycosylation
|
|
gptkbp:proteinFamily
|
gptkb:Wnt_family
|
|
gptkbp:RefSeq
|
NM_005430
|
|
gptkbp:regulates
|
cell fate determination
beta-catenin signaling
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:role
|
midbrain development
neural tube patterning
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:subcellularLocation
|
extracellular region
|
|
gptkbp:UniProtID
|
P04628
|
|
gptkbp:bfsParent
|
gptkb:FBgn0003204
|
|
gptkbp:bfsLayer
|
6
|