|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:solute_carrier_family_18_member_2
gptkb:SLC18A2
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
gptkb:depression
gptkb:Huntington's_disease
schizophrenia
|
|
gptkbp:cellularComponent
|
gptkb:cell_membrane
synaptic vesicle membrane
|
|
gptkbp:encodedBy
|
gptkb:SLC18A2
|
|
gptkbp:Entrez_Gene_ID
|
6571
|
|
gptkbp:expressedIn
|
brain
pancreatic beta cells
|
|
gptkbp:family
|
gptkb:solute_carrier_family_18
|
|
gptkbp:foundIn
|
synaptic vesicles
|
|
gptkbp:fullName
|
gptkb:Vesicular_monoamine_transporter_2
|
|
gptkbp:function
|
transports monoamines into synaptic vesicles
monoamine transmembrane transporter activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VMAT2
|
|
gptkbp:imagingBiomarker
|
PET imaging of dopaminergic neurons
|
|
gptkbp:inhibitedBy
|
gptkb:tetrabenazine
gptkb:reserpine
|
|
gptkbp:locatedOnChromosome
|
gptkb:human_chromosome_10q25
|
|
gptkbp:molecularWeight
|
~56 kDa
|
|
gptkbp:mutationAssociatedWith
|
neurological disorders
altered monoamine storage
|
|
gptkbp:OMIM
|
193001
|
|
gptkbp:orthologIn
|
gptkb:mouse_Slc18a2
gptkb:rat_Slc18a2
|
|
gptkbp:PDB
|
7MJS
|
|
gptkbp:relatedTo
|
gptkb:VMAT1
|
|
gptkbp:role
|
insulin secretion
neurotransmitter storage
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
12 transmembrane domains
|
|
gptkbp:targetOfDrug
|
antipsychotic drugs
antidepressant drugs
|
|
gptkbp:transportation
|
gptkb:histamine
dopamine
norepinephrine
serotonin
epinephrine
|
|
gptkbp:UniProtID
|
gptkb:P51809
|
|
gptkbp:bfsParent
|
gptkb:SLC18A2
gptkb:VMAT
|
|
gptkbp:bfsLayer
|
7
|