reserpine

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf alkaloid
antipsychotic medication
antihypertensive drug
gptkbp:ATCCode C02AA02
gptkbp:CASNumber 50-55-5
gptkbp:category estrogen
alkaloid
antihypertensive agent
World Health Organization essential medicine
antipsychotic agent
gptkbp:chemicalFormula C33H40N2O9
gptkbp:contraindication ulcerative colitis
electroconvulsive therapy
depressive disorders
active peptic ulcer
gptkbp:derivedFrom gptkb:Rauwolfia_serpentina
gptkbp:discoveredBy gptkb:Schlittler_and_Bein
1952
gptkbp:eliminationHalfLife 24–48 hours
gptkbp:excretion urine
feces
gptkbp:first_marketed 1954
https://www.w3.org/2000/01/rdf-schema#label reserpine
gptkbp:IUPACName gptkb:methyl_(3β,16β,17α,18β,20α)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]_yohimban-16-carboxylate
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction depletes monoamines from nerve terminals
gptkbp:meltingPoint 262–263 °C
gptkbp:metabolism liver
gptkbp:molecularWeight 608.7 g/mol
gptkbp:origin plant-derived
gptkbp:pregnancyCategory C (US)
gptkbp:PubChem_CID 5770
DB00206
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:depression
nasal congestion
drowsiness
bradycardia
gastrointestinal upset
gptkbp:solubility insoluble in water
soluble in alcohol
soluble in chloroform
gptkbp:synonym gptkb:Raudixin
gptkb:Serpasil
Sandril
gptkbp:UNII 8B1QWR724A
gptkbp:usedFor treatment of high blood pressure
treatment of psychotic states
gptkbp:bfsParent gptkb:Apocynaceae
gptkb:alkaloid
gptkbp:bfsLayer 6