Tumor suppressor p53-binding protein 1

URI: https://gptkb.org/entity/Tumor_suppressor_p53-binding_protein_1
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:TP53BP1
gptkbp:discoveredBy 1999
gptkbp:domain gptkb:Tudor_domain
gptkb:BRCT_domain
gptkbp:encodedBy TP53BP1 gene
gptkbp:Entrez_Gene_ID 7158
gptkbp:expressedIn various human tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function DNA damage response
double-strand break repair
cell cycle checkpoint control
https://www.w3.org/2000/01/rdf-schema#label Tumor suppressor p53-binding protein 1
gptkbp:interactsWith gptkb:p53_protein
gptkbp:involvedIn gptkb:non-homologous_end_joining
DNA repair
gptkbp:length 1972 amino acids
gptkbp:locale gptkb:nucleus
gptkbp:locatedOnChromosome 15q15-q21
gptkbp:molecularWeight 213 kDa
gptkbp:mutationAssociatedWith increased cancer risk
genomic instability
gptkbp:OMIM 605230
gptkbp:PDB 1XNI
gptkbp:phosphorylates gptkb:ATM_kinase
gptkb:ATR_kinase
gptkbp:roleInCancer tumor suppression
genome stability maintenance
gptkbp:UniProtID Q12888
gptkbp:bfsParent gptkb:TP53BP1
gptkb:53BP1
gptkbp:bfsLayer 8