Transcription Factor Sp1

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:alternativeName gptkb:SP1
gptkb:Specificity_Protein_1
Transcription factor Sp1
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes
gptkbp:binds GC-rich motifs
gptkbp:discoveredBy gptkb:Robert_Tjian
gptkbp:discoveredIn 1983
gptkbp:DNA_binding_domain zinc finger
gptkbp:Entrez_Gene_ID 6667
ENSG00000185591
gptkbp:expressedIn most human tissues
gptkbp:function transcriptional activation
regulation of gene expression
DNA binding
gptkbp:gene gptkb:SP1
https://www.w3.org/2000/01/rdf-schema#label Transcription Factor Sp1
gptkbp:interactsWith gptkb:CBP
gptkb:E2F1
gptkb:HDAC1
gptkb:p300
TAFII110
gptkbp:locatedOnChromosome 12q13.1
gptkbp:molecularWeight ~81 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:postTranslationalModification phosphorylation
glycosylation
sumoylation
acetylation
gptkbp:regulates differentiation
DNA repair
metabolism
cellular senescence
angiogenesis
cell growth
inflammation
immune response
housekeeping genes
chromatin remodeling
cell cycle genes
apoptosis-related genes
TATA-less promoters
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID P08047
gptkbp:bfsParent gptkb:SP1_gene
gptkbp:bfsLayer 8