|
gptkbp:instanceOf
|
gptkb:protein
transcription factor
|
|
gptkbp:abbreviation
|
gptkb:SP1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes
|
|
gptkbp:binds
|
GC-rich motifs
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Tjian
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:DNA_binding_motif
|
zinc finger
|
|
gptkbp:encodedBy
|
gptkb:SP1_gene
|
|
gptkbp:Entrez_Gene_ID
|
6667
ENSG00000185591
|
|
gptkbp:expressedIn
|
most tissues
|
|
gptkbp:function
|
transcriptional activation
regulation of gene expression
DNA binding
|
|
gptkbp:GO
|
GO:0005634
GO:0003700
GO:0006355
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Specificity Protein 1
|
|
gptkbp:interactsWith
|
gptkb:CBP/p300
gptkb:E2F1
gptkb:HDAC1
gptkb:p53
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
12q13.1
|
|
gptkbp:molecularWeight
|
~81 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1VA1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
sumoylation
acetylation
|
|
gptkbp:regulates
|
growth factors
hormones
methylation
oxidative stress
ubiquitination
housekeeping genes
apoptosis genes
cell cycle genes
proteasomal degradation
developmental genes
|
|
gptkbp:UniProtID
|
P08047
|
|
gptkbp:bfsParent
|
gptkb:SP1_gene
|
|
gptkbp:bfsLayer
|
8
|