|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:p73
gptkb:TP73
tumor protein p73
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:neuroblastoma
gptkb:cancer
|
|
gptkbp:chromosomeArm
|
gptkb:1p36
|
|
gptkbp:discoveredBy
|
Kaghad et al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodes
|
tumor protein p73
|
|
gptkbp:Entrez_Gene_ID
|
7161
ENSG00000078900
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
apoptosis
regulation of cell cycle
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasIsoform
|
gptkb:ΔNp73
gptkb:TAp73
|
|
gptkbp:HGNC_ID
|
HGNC:12003
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TP73 gene
|
|
gptkbp:involvedIn
|
immune response
neuronal development
DNA damage response
|
|
gptkbp:length
|
over 80 kb
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
|
|
gptkbp:mutationAssociatedWith
|
implicated in tumorigenesis
|
|
gptkbp:numberOfExons
|
15
|
|
gptkbp:OMIM
|
601990
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Trp73 gene
|
|
gptkbp:product
|
gptkb:p73
|
|
gptkbp:proteinFamily
|
DNA-binding domain
oligomerization domain
transactivation domain
SAM domain
transactivation inhibitory domain
|
|
gptkbp:regulates
|
apoptosis
cellular differentiation
cellular proliferation
p53-responsive elements
|
|
gptkbp:relatedTo
|
gptkb:TP53_gene
gptkb:TP63_gene
gptkb:p53_family
|
|
gptkbp:significance
|
biomarker for cancer prognosis
|
|
gptkbp:UniProtID
|
O15350
|
|
gptkbp:bfsParent
|
gptkb:p73
gptkb:TP63_gene
|
|
gptkbp:bfsLayer
|
7
|