TP63 gene

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alternativeName gptkb:p63
gptkb:KET
p40
TP73L
p51
Cleft lip/palate ectodermal dysplasia syndrome protein
gptkbp:associatedWith Ectrodactyly-ectodermal dysplasia-cleft syndrome (EEC)
Limb-mammary syndrome (LMS)
Rapp-Hodgkin syndrome
Split hand/foot malformation type 4 (SHFM4)
Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC)
gptkbp:biologicalProcess cell proliferation
apoptotic process
DNA-binding transcription factor activity
epithelial cell differentiation
gptkbp:discoveredBy Yang et al.
gptkbp:discoveredIn 1998
gptkbp:encodes gptkb:Tumor_protein_p63
gptkbp:Entrez_Gene_ID 8626
gptkbp:expressedIn gptkb:skin
gptkb:prostate
epithelial tissues
urothelium
gptkbp:function regulation of cell proliferation
transcription factor
regulation of epithelial development
gptkbp:geneType protein-coding
gptkbp:hasPseudogene yes
gptkbp:hasTranscriptVariant gptkb:ΔNp63
gptkb:TAp63
gptkbp:HGNC_ID HGNC:12003
https://www.w3.org/2000/01/rdf-schema#label TP63 gene
gptkbp:length 680 amino acids (canonical isoform)
gptkbp:locatedOnChromosome gptkb:chromosome_3
3q28
gptkbp:molecularWeight 75 kDa (approximate)
gptkbp:mutationAssociatedWith developmental disorders
congenital malformations
gptkbp:OMIM 603273
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn mouse Trp63
zebrafish tp63
gptkbp:proteinFamily gptkb:p53_family
gptkbp:regulates apoptosis
stem cell maintenance
cell cycle arrest
epidermal differentiation
gptkbp:relatedTo gptkb:TP53_gene
gptkb:TP73_gene
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID gptkb:Q9H3D4
gptkbp:bfsParent gptkb:p63
gptkbp:bfsLayer 6