Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alias |
gptkb:p63
gptkb:KET p40 p51 |
| gptkbp:alternativeSplicing |
produces multiple isoforms
|
| gptkbp:associatedWith |
ectodermal dysplasia
limb-mammary syndrome ankyloblepharon-ectodermal defects-cleft lip/palate syndrome |
| gptkbp:discoveredBy |
1998
|
| gptkbp:Entrez_Gene_ID |
8626
|
| gptkbp:expressedIn |
epithelial tissues
|
| gptkbp:function |
apoptosis
regulation of cell cycle transcription factor epithelial development |
| gptkbp:gene |
gptkb:TP63
|
| gptkbp:HGNC_ID |
HGNC:11999
|
| gptkbp:homolog_of |
gptkb:p73
gptkb:p53 |
| https://www.w3.org/2000/01/rdf-schema#label |
Tumor protein p63
|
| gptkbp:involves |
craniofacial development
limb development skin development urogenital development |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_3
3q28 |
| gptkbp:molecularWeight |
~68 kDa
|
| gptkbp:mutationAssociatedWith |
developmental syndromes
|
| gptkbp:OMIM |
603273
|
| gptkbp:proteinFamily |
gptkb:p53_family
|
| gptkbp:regulates |
cell survival
cellular senescence cell migration cell adhesion differentiation of epithelial cells epidermal morphogenesis epithelial stem cell maintenance proliferation of basal keratinocytes stratification of epithelia |
| gptkbp:structure |
contains DNA-binding domain
contains oligomerization domain contains sterile alpha motif (SAM) domain contains transactivation domain contains transactivation inhibitory domain (TID) |
| gptkbp:subcellularLocation |
gptkb:nucleus
|
| gptkbp:UniProtID |
gptkb:Q9H3D4
|
| gptkbp:bfsParent |
gptkb:p63
|
| gptkbp:bfsLayer |
6
|