|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:TEK
|
|
gptkbp:associatedWith
|
gptkb:hereditary_hemorrhagic_telangiectasia
gptkb:primary_congenital_glaucoma
|
|
gptkbp:component
|
integral component of plasma membrane
|
|
gptkbp:discoveredBy
|
Sato et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:TEK_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000120156
|
|
gptkbp:expressedIn
|
endothelial cells
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
gptkb:angiopoietin_receptor
transmembrane receptor protein tyrosine kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
blood vessel morphogenesis
|
|
gptkbp:HGNC_ID
|
11740
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TIE2
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:SHC1
gptkb:angiopoietin-2
gptkb:VE-PTP
gptkb:GRB2
gptkb:angiopoietin-1
gptkb:DOK2
|
|
gptkbp:involvedIn
|
angiogenesis
vascular development
|
|
gptkbp:ligand
|
gptkb:angiopoietin-2
gptkb:angiopoietin-1
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9q21
|
|
gptkbp:memberOf
|
gptkb:TIE_receptor_family
|
|
gptkbp:molecularWeight
|
~145 kDa
|
|
gptkbp:mutationAssociatedWith
|
venous malformations
|
|
gptkbp:OMIM
|
600221
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2GY7
|
|
gptkbp:phosphorylates
|
gptkb:Y1102
gptkb:Y1108
Y1111
|
|
gptkbp:regulates
|
endothelial cell survival
activated by angiopoietin-1
inhibited by angiopoietin-2
vascular stability
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:Q02763
|
|
gptkbp:bfsParent
|
gptkb:cabozantinib
|
|
gptkbp:bfsLayer
|
6
|