|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:SCL
|
|
gptkbp:associatedWith
|
gptkb:T-cell_acute_lymphoblastic_leukemia
|
|
gptkbp:clinicalTrialPhase
|
FISH for TAL1 translocation
RT-PCR for TAL1 expression
|
|
gptkbp:discoveredBy
|
gptkb:Aplan_et_al.
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodes
|
gptkb:TAL1_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:TAL1
6886
ENSG00000162367
|
|
gptkbp:expressedIn
|
endothelial cells
hematopoietic stem cells
|
|
gptkbp:fullName
|
gptkb:T-cell_acute_lymphocytic_leukemia_protein_1
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasDNA-bindingDomain
|
basic helix-loop-helix (bHLH) domain
|
|
gptkbp:hasDrosophilaHomolog
|
gptkb:daughterless
|
|
gptkbp:hasPseudogene
|
gptkb:TAL1P1
|
|
gptkbp:hasYeastHomolog
|
none
|
|
gptkbp:HGNC_ID
|
11531
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TAL1
|
|
gptkbp:interactsWith
|
gptkb:GATA1
gptkb:LMO2
gptkb:E47
gptkb:ETO
gptkb:LDB1
|
|
gptkbp:involvedIn
|
hematopoiesis
|
|
gptkbp:length
|
6 exons
331 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p32
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:mutationAssociatedWith
|
chromosomal band
deletion
point mutation
|
|
gptkbp:OMIM
|
187040
|
|
gptkbp:orthologInMouse
|
gptkb:Tal1
|
|
gptkbp:orthologInZebrafish
|
tal1
|
|
gptkbp:pathway
|
gptkb:hematopoietic_cell_lineage
transcriptional misregulation in cancer
|
|
gptkbp:PDB
|
2YPA
|
|
gptkbp:proteinFamily
|
bHLH transcription factors
|
|
gptkbp:RefSeq
|
NM_003189
|
|
gptkbp:regulates
|
CD34 expression
GATA2 expression
RUNX1 expression
downregulated in mature T-cells
erythroid differentiation
megakaryocyte differentiation
upregulated in leukemia
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:therapeuticArea
|
leukemia therapy
|
|
gptkbp:transcriptionStartSite
|
chr1:47,205,000 (GRCh38)
|
|
gptkbp:UniProtID
|
P17542
|
|
gptkbp:bfsParent
|
gptkb:HBB
|
|
gptkbp:bfsLayer
|
6
|