T-cell large granular lymphocyte leukemia

URI: https://gptkb.org/entity/T-cell_large_granular_lymphocyte_leukemia
GPTKB entity
Statements (37)
Predicate Object
gptkbp:instanceOf gptkb:disease
leukemia
lymphoproliferative disorder
gptkbp:affects gptkb:T-cells
blood
gptkbp:causedBy clonal proliferation of cytotoxic T-cells
gptkbp:hasCellMarker CD16+
CD57+
CD8+
gptkbp:hasDiagnosticMethod peripheral blood smear
flow cytometry
T-cell receptor gene rearrangement
gptkbp:hasSexRatio slight male predominance
https://www.w3.org/2000/01/rdf-schema#label T-cell large granular lymphocyte leukemia
gptkbp:ICD-10_code gptkb:C91.8
gptkbp:medianAge 60 years
gptkbp:originatedIn CD3+ T-cells
gptkbp:prevalence rare
gptkbp:prognosis chronic disease
indolent course
gptkbp:riskFactor autoimmune disease
rheumatoid arthritis
gptkbp:subclassOf gptkb:large_granular_lymphocyte_leukemia
gptkbp:symptom gptkb:anemia
fatigue
splenomegaly
neutropenia
recurrent infections
gptkbp:synonym gptkb:T-LGL_leukemia
gptkbp:treatment gptkb:cyclophosphamide
gptkb:cyclosporine
gptkb:prednisone
gptkb:methotrexate
immunosuppressive therapy
gptkbp:bfsParent gptkb:Large_Granular_Lymphocyte_Leukemia
gptkb:T-cell_LGL_Leukemia
gptkbp:bfsLayer 8