large granular lymphocyte leukemia

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease leukemia
gptkbp:affects	blood bone marrow lymphocytes
gptkbp:alsoKnownAs	gptkb:LGL_leukemia
gptkbp:associatedWith	autoimmune disorders rheumatoid arthritis
gptkbp:characterizedBy	clonal proliferation of large granular lymphocytes
gptkbp:diagnosedBy	bone marrow biopsy immunophenotyping blood smear flow cytometry
gptkbp:firstDescribed	1985
gptkbp:hasAcuteForm	acute large granular lymphocyte leukemia
gptkbp:hasChronicForm	chronic large granular lymphocyte leukemia
gptkbp:hasEpidemiology	rare
gptkbp:hasRelatedCondition	pure red cell aplasia Felty's syndrome
https://www.w3.org/2000/01/rdf-schema#label	large granular lymphocyte leukemia
gptkbp:ICD-10_code	C91.7
gptkbp:incidence	less than 1 per million per year
gptkbp:medianAge	60 years
gptkbp:MeSH_ID	D016397
gptkbp:mutationAssociatedWith	gptkb:STAT3_mutation gptkb:STAT5b_mutation
gptkbp:OMIM	608098
gptkbp:originatedIn	gptkb:natural_killer_cells T lymphocytes
gptkbp:prognosis	generally indolent can be chronic
gptkbp:subspecies	gptkb:T-cell_large_granular_lymphocyte_leukemia leukemia chronic lymphoproliferative disorder of NK cells
gptkbp:symptom	gptkb:anemia fatigue splenomegaly neutropenia recurrent infections
gptkbp:treatment	gptkb:cyclophosphamide gptkb:rituximab gptkb:cyclosporine gptkb:prednisone gptkb:methotrexate immunosuppressive therapy
gptkbp:bfsParent	gptkb:NK-cell_LGL_Leukemia
gptkbp:bfsLayer	8