Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
leukemia lymphoproliferative disorder |
| gptkbp:affects |
gptkb:T_cells
|
| gptkbp:associatedWith |
gptkb:anemia
autoimmune disorders splenomegaly neutropenia rheumatoid arthritis |
| gptkbp:cellType |
CD3+ T cells
CD8+ cytotoxic T cells |
| gptkbp:characterizedBy |
clonal proliferation of large granular lymphocytes
|
| gptkbp:commonMarker |
gptkb:CD3
gptkb:CD8 gptkb:CD57 CD16 TCR alpha/beta |
| gptkbp:diagnosedBy |
peripheral blood smear
flow cytometry T-cell receptor gene rearrangement studies |
| gptkbp:differentialDiagnosis |
myelodysplastic syndrome
chronic lymphocytic leukemia NK-LGL leukemia |
| gptkbp:firstDescribed |
1985
|
| gptkbp:fullName |
gptkb:T-cell_large_granular_lymphocytic_leukemia
|
| gptkbp:gender |
slightly more common in males
|
| https://www.w3.org/2000/01/rdf-schema#label |
T-LGL leukemia
|
| gptkbp:ICD-10_code |
gptkb:C91.8
|
| gptkbp:incidence |
rare
|
| gptkbp:medianAge |
60 years
|
| gptkbp:mutationAssociatedWith |
gptkb:STAT3_mutation
gptkb:STAT5b_mutation |
| gptkbp:notableFeature |
can be associated with Felty's syndrome
can be associated with pure red cell aplasia can be asymptomatic chronic course often requires long-term management |
| gptkbp:prevalence |
less than 5% of all chronic lymphoproliferative disorders
|
| gptkbp:prognosis |
generally indolent
|
| gptkbp:symptom |
fatigue
recurrent infections cytopenias |
| gptkbp:treatment |
gptkb:cyclophosphamide
gptkb:cyclosporine gptkb:prednisone gptkb:methotrexate immunosuppressive therapy |
| gptkbp:bfsParent |
gptkb:T-cell_LGL_Leukemia
|
| gptkbp:bfsLayer |
8
|