Large Granular Lymphocyte Leukemia

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease leukemia
gptkbp:affects	blood lymphocytes
gptkbp:affectsGender	both males and females
gptkbp:alsoKnownAs	gptkb:LGL_leukemia
gptkbp:associatedWith	gptkb:STAT3_mutation gptkb:STAT5b_mutation autoimmune disorders rheumatoid arthritis
gptkbp:characterizedBy	abnormal proliferation of large granular lymphocytes
gptkbp:diagnosedBy	bone marrow biopsy blood smear flow cytometry
gptkbp:firstDescribed	1977
gptkbp:hasEpidemiology	rare
https://www.w3.org/2000/01/rdf-schema#label	Large Granular Lymphocyte Leukemia
gptkbp:ICD-10_code	gptkb:C91.8
gptkbp:incidence	less than 1 per million per year
gptkbp:medianAge	60 years
gptkbp:MeSH_ID	D016397
gptkbp:OMIM	608098
gptkbp:prognosis	generally indolent
gptkbp:subspecies	gptkb:NK-cell_large_granular_lymphocyte_leukemia gptkb:T-cell_large_granular_lymphocyte_leukemia chronic lymphoproliferative disorder
gptkbp:symptom	gptkb:anemia splenomegaly neutropenia recurrent infections
gptkbp:treatment	gptkb:cyclophosphamide gptkb:cyclosporine gptkb:prednisone gptkb:methotrexate immunosuppressive therapy
gptkbp:bfsParent	gptkb:LGL_Leukemia gptkb:Large_Granular_Lymphocyte
gptkbp:bfsLayer	7