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gptkbp:instanceOf
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gptkb:leukemia
gptkb:disease
|
|
gptkbp:affects
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gptkb:T-lymphocytes
|
|
gptkbp:alternativeName
|
gptkb:T-cell_large_granular_lymphocyte_leukemia
gptkb:T-LGLL
gptkb:T-LGL_leukemia
|
|
gptkbp:associatedWith
|
gptkb:anemia
autoimmune disorders
splenomegaly
neutropenia
rheumatoid arthritis
|
|
gptkbp:characterizedBy
|
clonal proliferation of large granular lymphocytes
|
|
gptkbp:diagnosedBy
|
blood smear
flow cytometry
T-cell receptor gene rearrangement analysis
|
|
gptkbp:firstDescribed
|
1985
|
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gptkbp:hasCellMarker
|
gptkb:CD3
gptkb:CD8
gptkb:CD57
CD16
|
|
gptkbp:hasEpidemiology
|
rare
|
|
gptkbp:ICD-10_code
|
gptkb:C91.8
|
|
gptkbp:medianAge
|
60 years
|
|
gptkbp:mutationAssociatedWith
|
gptkb:STAT3_mutation
gptkb:STAT5b_mutation
|
|
gptkbp:prognosis
|
indolent course
|
|
gptkbp:subspecies
|
chronic lymphoproliferative disorder
|
|
gptkbp:symptom
|
fatigue
weight loss
night sweats
recurrent infections
|
|
gptkbp:treatment
|
gptkb:cyclophosphamide
gptkb:cyclosporine
gptkb:prednisone
gptkb:methotrexate
immunosuppressive therapy
|
|
gptkbp:bfsParent
|
gptkb:LGL_Leukemia
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
T-cell LGL Leukemia
|