|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:t-PA
gptkb:tissue-type_plasminogen_activator
gptkb:tPA
|
|
gptkbp:approvalYear
|
1987
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:CASNumber
|
105857-23-6
|
|
gptkbp:category
|
gptkb:enzyme
biological drug
fibrinolytic agent
|
|
gptkbp:contraindication
|
active internal bleeding
history of hemorrhagic stroke
|
|
gptkbp:discoveredBy
|
S. Sherry et al.
|
|
gptkbp:drugForm
|
gptkb:alteplase
gptkb:reteplase
gptkb:tenecteplase
|
|
gptkbp:EC_number
|
3.4.21.68
|
|
gptkbp:foundIn
|
human plasma
|
|
gptkbp:fullName
|
gptkb:tissue_plasminogen_activator
|
|
gptkbp:function
|
gptkb:serine_protease
converts plasminogen to plasmin
|
|
gptkbp:gene
|
gptkb:PLAT
|
|
gptkbp:halfLife
|
~5 minutes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
T-PA
|
|
gptkbp:indication
|
gptkb:acute_myocardial_infarction
acute ischemic stroke
massive pulmonary embolism
|
|
gptkbp:locatedOnChromosome
|
gptkb:8p11.21
|
|
gptkbp:marketedAs
|
gptkb:Genentech
|
|
gptkbp:mechanismOfAction
|
cleaves Arg561-Val562 bond in plasminogen
|
|
gptkbp:medicalUse
|
thrombolysis
|
|
gptkbp:molecularWeight
|
~70 kDa
|
|
gptkbp:orthologIn
|
gptkb:lion
gptkb:mouse
right
|
|
gptkbp:PDB
|
gptkb:1TPA
|
|
gptkbp:producedBy
|
recombinant DNA technology
endothelial cells
|
|
gptkbp:riskFactor
|
intracranial hemorrhage
|
|
gptkbp:role
|
dissolves blood clots
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
bleeding
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:UniProtID
|
P00750
|
|
gptkbp:usedFor
|
treatment of pulmonary embolism
treatment of ischemic stroke
treatment of myocardial infarction
|
|
gptkbp:bfsParent
|
gptkb:PLAT
|
|
gptkbp:bfsLayer
|
7
|