tissue-type plasminogen activator

URI: https://gptkb.org/entity/tissue-type_plasminogen_activator
GPTKB entity
Statements (35)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:tPA
gptkbp:approvedBy gptkb:FDA
gptkbp:associatedWith myocardial infarction
pulmonary embolism
ischemic stroke
gptkbp:CASNumber 105857-23-6
gptkbp:category gptkb:enzyme
therapeutic protein
fibrinolytic agent
gptkbp:contraindication active internal bleeding
history of hemorrhagic stroke
gptkbp:discoveredBy S. Sherry et al.
gptkbp:discoveredIn 1979
gptkbp:drug_form gptkb:alteplase
gptkb:reteplase
gptkb:tenecteplase
gptkbp:EC_number 3.4.21.68
gptkbp:function gptkb:serine_protease
converts plasminogen to plasmin
gptkbp:gene gptkb:PLAT
gptkbp:GO_term GO:0004252
https://www.w3.org/2000/01/rdf-schema#label tissue-type plasminogen activator
gptkbp:locatedOnChromosome gptkb:chromosome_8p12-p11.2
gptkbp:medical_risk bleeding
gptkbp:molecularWeight ~70 kDa
gptkbp:producedBy endothelial cells
gptkbp:structure contains kringle domains
contains serine protease domain
gptkbp:UniProtID P00750
gptkbp:usedFor treatment of pulmonary embolism
treatment of ischemic stroke
treatment of myocardial infarction
gptkbp:bfsParent gptkb:PLAT
gptkbp:bfsLayer 7