|
gptkbp:instanceOf
|
superfamily
|
|
gptkbp:alternativeTo
|
chaperone activity
hormone transport
|
|
gptkbp:conservedIn
|
reactive center loop
|
|
gptkbp:database
|
gptkb:MEROPS_family_I4
|
|
gptkbp:discoveredBy
|
gptkb:Hans_Fritz
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:example
|
gptkb:plasminogen_activator_inhibitor-1
gptkb:alpha-1_antitrypsin
gptkb:antithrombin
gptkb:neuroserpin
gptkb:C1-inhibitor
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
plants
viruses
|
|
gptkbp:fullName
|
gptkb:serine_protease_inhibitors
|
|
gptkbp:function
|
inhibit serine proteases
regulate proteolytic pathways
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Serpins
|
|
gptkbp:mechanismOfAction
|
suicide substrate mechanism
|
|
gptkbp:mutationAssociatedWith
|
serpinopathies
|
|
gptkbp:numberOfMembers
|
over 1000
|
|
gptkbp:OMIM
|
107400
|
|
gptkbp:proteinFamily
|
gptkb:SERPINA
gptkb:SERPINB
gptkb:SERPINC
gptkb:SERPIND
gptkb:SERPINE
gptkb:SERPINF
PF00079
SERPING
SERPINH
SERPINI
SERPINI1
SERPINK
SERPINL
|
|
gptkbp:relatedTo
|
apoptosis
cell migration
inflammation
immune response
blood coagulation
|
|
gptkbp:significance
|
gptkb:Alzheimer's_disease
gptkb:cancer
emphysema
inflammatory diseases
thrombosis
liver cirrhosis
angioedema
|
|
gptkbp:structure
|
predominantly alpha-helical
reactive center loop
|
|
gptkbp:bfsParent
|
gptkb:Lousã
|
|
gptkbp:bfsLayer
|
7
|