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gptkbp:instanceOf
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gptkb:enzyme
|
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gptkbp:alternativeName
|
gptkb:Manganese_superoxide_dismutase
gptkb:MnSOD
SOD-2
Superoxide dismutase 2
|
|
gptkbp:associatedWith
|
gptkb:cancer
amyotrophic lateral sclerosis
cardiomyopathy
|
|
gptkbp:catalyzes
|
dismutation of superoxide into oxygen and hydrogen peroxide
|
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gptkbp:cofactor
|
manganese
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gptkbp:discoveredBy
|
gptkb:Irwin_Fridovich
|
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gptkbp:discoveredIn
|
1969
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gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:encodedBy
|
gptkb:SOD2_gene
|
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gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000112096
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gptkbp:expressedIn
|
all human tissues
|
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gptkbp:fullName
|
Superoxide dismutase [Mn], mitochondrial
|
|
gptkbp:function
|
antioxidant defense
|
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gptkbp:gene
|
gptkb:SOD2
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gptkbp:GO_term
|
GO:0004789
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gptkbp:highestExpression
|
gptkb:kidney
heart
liver
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOD2 (Mn-SOD)
|
|
gptkbp:inhibitedBy
|
by hydrogen peroxide
|
|
gptkbp:locatedIn
|
mitochondrion
|
|
gptkbp:locatedOnChromosome
|
6q25.3
|
|
gptkbp:molecularWeight
|
24 kDa (monomer)
|
|
gptkbp:mutationAssociatedWith
|
mitochondrial dysfunction
increased oxidative stress
|
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gptkbp:OMIM
|
147460
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
present in most eukaryotes
|
|
gptkbp:PDB
|
gptkb:1LUV
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:iron/manganese_superoxide_dismutase_family
|
|
gptkbp:RefSeq
|
NP_000627.2
|
|
gptkbp:regulates
|
induced by oxidative stress
regulated by NF-κB
regulated by FOXO3
|
|
gptkbp:significance
|
implicated in aging
implicated in neurodegenerative diseases
mutations cause SOD2 deficiency
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:subcellularLocation
|
mitochondrial matrix
|
|
gptkbp:UniProtID
|
P04179
|
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gptkbp:bfsParent
|
gptkb:Cu,Zn-SOD
|
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gptkbp:bfsLayer
|
7
|