Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activeSiteResidue |
gptkb:Serine
|
| gptkbp:associatedWith |
gptkb:extended-spectrum_beta-lactamases_(ESBLs)
|
| gptkbp:confers_resistance_to |
gptkb:cephalosporins
penicillins |
| gptkbp:encodedBy |
chromosomes
plasmids |
| gptkbp:firstDescribed |
1970s
|
| gptkbp:foundIn |
gptkb:Bacteria
gptkb:Klebsiella_pneumoniae other Gram-negative bacteria |
| gptkbp:function |
hydrolyze beta-lactam antibiotics
|
| gptkbp:gene |
blaSHV
|
| https://www.w3.org/2000/01/rdf-schema#label |
SHV beta-lactamases
|
| gptkbp:inhibitedBy |
gptkb:clavulanic_acid
tazobactam |
| gptkbp:molecularWeight |
~29 kDa
|
| gptkbp:nameOrigin |
sulfhydryl variable
|
| gptkbp:relatedTo |
TEM beta-lactamases
|
| gptkbp:significance |
antibiotic resistance
|
| gptkbp:subclassOf |
class A beta-lactamases
|
| gptkbp:variant_examples |
gptkb:SHV-1
gptkb:SHV-2 gptkb:SHV-5 SHV-12 |
| gptkbp:bfsParent |
gptkb:SHV-1
|
| gptkbp:bfsLayer |
8
|