|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
PTPN11 protein
Src homology region 2-containing protein tyrosine phosphatase-2
|
|
gptkbp:associatedWith
|
gptkb:LEOPARD_syndrome
gptkb:juvenile_myelomonocytic_leukemia
gptkb:Noonan_syndrome
|
|
gptkbp:discoveredBy
|
Nicholas K. Tonks
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:domain
|
gptkb:protein_tyrosine_phosphatase_domain
SH2 domain
|
|
gptkbp:encodedBy
|
gptkb:PTPN11_gene
|
|
gptkbp:Entrez_Gene_ID
|
5781
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:hasBiologicalActivity
|
protein tyrosine phosphatase activity
|
|
gptkbp:interactsWith
|
gptkb:EGFR
gptkb:PDGFR
gptkb:Gab1
gptkb:Grb2
SHP-1 protein
|
|
gptkbp:involvedIn
|
gptkb:RAS/MAPK_pathway
cell differentiation
cell migration
cell signaling
cell growth regulation
hematopoiesis
|
|
gptkbp:molecularWeight
|
~68 kDa
|
|
gptkbp:mutationAssociatedWith
|
D61G
E76K
N308D
|
|
gptkbp:orthologIn
|
Drosophila corkscrew protein
|
|
gptkbp:PDB
|
2SHP
4DGP
|
|
gptkbp:phosphorylatedAt
|
tyrosine residues
|
|
gptkbp:regulates
|
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
gptkb:ERK_pathway
insulin signaling
growth factor signaling
cytokine signaling
|
|
gptkbp:requires
|
embryonic development
hematopoietic stem cell function
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:target
|
cancer therapeutics
phosphatase inhibitors
|
|
gptkbp:UniProtID
|
Q06124
|
|
gptkbp:bfsParent
|
gptkb:PTPN11
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SHP-2 protein
|