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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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PTPN11 protein
Src homology region 2-containing protein tyrosine phosphatase-2
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gptkbp:associatedWith
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gptkb:LEOPARD_syndrome
gptkb:juvenile_myelomonocytic_leukemia
gptkb:Noonan_syndrome
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gptkbp:discoveredBy
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Nicholas K. Tonks
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gptkbp:discoveredIn
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1993
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gptkbp:domain
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gptkb:protein_tyrosine_phosphatase_domain
SH2 domain
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gptkbp:encodedBy
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gptkb:PTPN11_gene
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gptkbp:Entrez_Gene_ID
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5781
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gptkbp:expressedIn
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various tissues
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gptkbp:foundIn
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gptkb:Mus_musculus
gptkb:Homo_sapiens
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gptkbp:hasBiologicalActivity
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protein tyrosine phosphatase activity
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https://www.w3.org/2000/01/rdf-schema#label
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SHP-2 protein
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gptkbp:interactsWith
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gptkb:EGFR
gptkb:PDGFR
gptkb:Gab1
gptkb:Grb2
SHP-1 protein
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gptkbp:involvedIn
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gptkb:RAS/MAPK_pathway
cell differentiation
cell migration
cell signaling
cell growth regulation
hematopoiesis
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gptkbp:molecularWeight
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~68 kDa
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gptkbp:mutationAssociatedWith
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D61G
E76K
N308D
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gptkbp:orthologIn
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Drosophila corkscrew protein
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gptkbp:PDB
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2SHP
4DGP
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gptkbp:phosphorylatedAt
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tyrosine residues
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gptkbp:regulates
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gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
gptkb:ERK_pathway
insulin signaling
growth factor signaling
cytokine signaling
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gptkbp:requires
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embryonic development
hematopoietic stem cell function
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gptkbp:subcellularLocation
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gptkb:cytoplasm
gptkb:plasma_membrane
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gptkbp:target
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cancer therapeutics
phosphatase inhibitors
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gptkbp:UniProtID
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Q06124
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gptkbp:bfsParent
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gptkb:PTPN11
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gptkbp:bfsLayer
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7
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