|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activeSiteResidue
|
gptkb:His41
Cys145
|
|
gptkbp:alsoKnownAs
|
gptkb:3CLpro
gptkb:Mpro
|
|
gptkbp:cleavageSites
|
11 sites in ORF1ab polyprotein
|
|
gptkbp:discoveredIn
|
2019
|
|
gptkbp:EC_number
|
3.4.22.69
|
|
gptkbp:encodedBy
|
gptkb:ORF1ab_polyprotein
|
|
gptkbp:enzymeClassification
|
gptkb:cysteine_protease
|
|
gptkbp:expressedIn
|
infected host cells
|
|
gptkbp:function
|
cleaves viral polyproteins at specific sites
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SARS-CoV-2 main protease
|
|
gptkbp:inhibitedBy
|
gptkb:Boceprevir
gptkb:GC376
gptkb:Nirmatrelvir
|
|
gptkbp:locatedOnChromosome
|
gptkb:SARS-CoV-2_genome
|
|
gptkbp:molecularWeight
|
33.8 kDa
|
|
gptkbp:organism
|
gptkb:COVID-19
|
|
gptkbp:PDB
|
gptkb:6LU7
6Y2E
7BQY
|
|
gptkbp:relatedTo
|
gptkb:MERS-CoV_main_protease
gptkb:SARS-CoV_main_protease
|
|
gptkbp:requires
|
viral replication
|
|
gptkbp:sequence
|
306 amino acids
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
Gln-(Ser,Ala,Gly) peptide bonds
|
|
gptkbp:targetOfDrug
|
COVID-19 antiviral drugs
|
|
gptkbp:UniProtID
|
P0DTD1
|
|
gptkbp:usedIn
|
structure-based drug design
|
|
gptkbp:bfsParent
|
gptkb:nirmatrelvir/ritonavir
|
|
gptkbp:bfsLayer
|
6
|