|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activeSiteResidue
|
gptkb:His41
Cys145
|
|
gptkbp:alsoKnownAs
|
gptkb:3CLpro
gptkb:Mpro
|
|
gptkbp:biologicalProcess
|
cysteine protease activity
|
|
gptkbp:cleavageSites
|
11 sites in polyprotein
|
|
gptkbp:discoveredIn
|
2003
|
|
gptkbp:EC_number
|
3.4.22.69
|
|
gptkbp:encodedBy
|
SARS-CoV genome
|
|
gptkbp:family
|
peptidase C30 family
|
|
gptkbp:function
|
cleaves viral polyproteins
|
|
gptkbp:gene
|
gptkb:nsp5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SARS-CoV main protease
|
|
gptkbp:inhibitedBy
|
gptkb:PF-07321332
gptkb:N3_inhibitor
gptkb:GC376
target for antiviral drugs
|
|
gptkbp:length
|
306 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:ORF1ab_polyprotein
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
33.8 kDa
|
|
gptkbp:organism
|
gptkb:SARS-CoV
|
|
gptkbp:orthologIn
|
gptkb:MERS-CoV_main_protease
|
|
gptkbp:PDB
|
1UK3
2AMQ
2C3S
|
|
gptkbp:relatedTo
|
gptkb:SARS-CoV-2_main_protease
|
|
gptkbp:requires
|
viral replication
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrateRecognition
|
Leu-Gln↓(Ser,Ala,Gly)
|
|
gptkbp:targetOfDrug
|
COVID-19 therapeutics
|
|
gptkbp:UniProtID
|
P0C6U8
|
|
gptkbp:bfsParent
|
gptkb:SARS-CoV-2_main_protease
|
|
gptkbp:bfsLayer
|
7
|