|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
gptkb:His41
Cys145
|
|
gptkbp:alternativeName
|
gptkb:3C-like_protease
main protease
|
|
gptkbp:biologicalProcess
|
cysteine protease activity
|
|
gptkbp:cleavage
|
Leu-Gln↓(Ser,Ala,Gly)
|
|
gptkbp:containsGene
|
ORF1a
ORF1ab
|
|
gptkbp:discoveredIn
|
2003
|
|
gptkbp:domain
|
C-terminal helical domain
chymotrypsin-like fold
|
|
gptkbp:EC_number
|
3.4.22.69
|
|
gptkbp:encodedBy
|
coronavirus genome
|
|
gptkbp:expressedIn
|
infected host cells
|
|
gptkbp:foundIn
|
gptkb:COVID-19
gptkb:MERS-CoV
gptkb:SARS-CoV
|
|
gptkbp:function
|
cleaves viral polyprotein
|
|
gptkbp:GOID
|
GO:0004197
GO:0016787
|
|
gptkbp:hasPfamID
|
PF05409
|
|
gptkbp:hasRole
|
viral pathogenesis
viral assembly
viral life cycle
viral maturation
viral protein processing
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
3CLpro
|
|
gptkbp:inhibitedBy
|
gptkb:nirmatrelvir
gptkb:GC376
gptkb:boceprevir
PF-00835231
|
|
gptkbp:InterPro
|
IPR021590
|
|
gptkbp:KEGGID
|
K19209
|
|
gptkbp:length
|
306
|
|
gptkbp:molecularWeight
|
33.8 kDa
|
|
gptkbp:orthologIn
|
picornavirus 3C protease
|
|
gptkbp:PDB
|
gptkb:6LU7
7BQY
7K3T
|
|
gptkbp:Reactome
|
R-HSA-9679506
|
|
gptkbp:requires
|
coronavirus replication
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
viral polyprotein
|
|
gptkbp:target
|
antiviral drug development
|
|
gptkbp:UniProtID
|
P0DTD1 (SARS-CoV-2)
|
|
gptkbp:bfsParent
|
gptkb:SARS-CoV-2_main_protease
gptkb:NSP5
|
|
gptkbp:bfsLayer
|
7
|