|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alias
|
gptkb:RhoA
gptkb:Ras_homolog_family_member_A
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
neurodegenerative disease
|
|
gptkbp:biologicalProcess
|
GTP binding
GTPase activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:decommissioned
|
gptkb:GDP_dissociation_inhibitors_(GDIs)
GTPase-activating proteins (GAPs)
|
|
gptkbp:encodedBy
|
gptkb:RHOA_gene
|
|
gptkbp:firstDescribed
|
1985
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cell cycle progression
cell migration
gene expression regulation
cell adhesion
regulation of actin cytoskeleton
|
|
gptkbp:gene
|
gptkb:RHOA
|
|
gptkbp:HGNC_ID
|
HGNC:667
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Rhoa
|
|
gptkbp:interactsWith
|
gptkb:ROCK1
gptkb:ROCK2
gptkb:ARHGEF1
ARHGEF2
p190RhoGAP
GDI proteins
mDia1
|
|
gptkbp:length
|
193 amino acids
|
|
gptkbp:locatedOnChromosome
|
3p21.31
|
|
gptkbp:memberOf
|
gptkb:Rho_family
small molecule
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:postTranslationalModification
|
prenylation
phosphorylation
|
|
gptkbp:regulates
|
transcription factors
cell shape
cell polarity
cytokinesis
stress fiber formation
focal adhesion assembly
|
|
gptkbp:structure
|
GTPase domain
C-terminal CAAX motif
|
|
gptkbp:UniProtID
|
P61586
|
|
gptkbp:bfsParent
|
gptkb:RHOA_gene
|
|
gptkbp:bfsLayer
|
7
|