|
gptkbp:instanceOf
|
gptkb:protein
guanine nucleotide exchange factor
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alternativeName
|
gptkb:Ras_homolog_family_member_A
Transforming protein RhoA
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
gptkb:GDP_dissociation_inhibitors_(GDIs)
GTPase-activating proteins (GAPs)
|
|
gptkbp:encodedBy
|
gptkb:RHOA_gene
|
|
gptkbp:function
|
cell cycle progression
cell migration
cell polarity
cell adhesion
regulation of actin cytoskeleton
transcriptional regulation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RhoA protein
|
|
gptkbp:interactsWith
|
gptkb:ROCK1
gptkb:ROCK2
Citron kinase
PKN1
mDia1
|
|
gptkbp:involvedIn
|
wound healing
cancer progression
neuronal development
immune cell trafficking
|
|
gptkbp:length
|
193 amino acids
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
3p21.31 (human)
|
|
gptkbp:memberOf
|
gptkb:Rho_family
gptkb:small_GTPase_superfamily
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
cardiovascular diseases
neurological disorders
|
|
gptkbp:postTranslationalModification
|
prenylation
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
cell shape
cell motility
stress fiber formation
focal adhesion assembly
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
G domain
C-terminal CAAX motif
|
|
gptkbp:UniProtID
|
P61586
|
|
gptkbp:bfsParent
|
gptkb:RhoA_signaling_pathway
gptkb:RHOA_gene
|
|
gptkbp:bfsLayer
|
7
|