|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:RSPO3
CRISTIN3
|
|
gptkbp:associatedWith
|
gptkb:familial_exudative_vitreoretinopathy
colorectal cancer
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodes
|
R-spondin-3 protein
|
|
gptkbp:Entrez_Gene_ID
|
84870
ENSG00000169242
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:placenta
heart
endothelial cells
|
|
gptkbp:fullName
|
R-spondin 3
|
|
gptkbp:function
|
regulates angiogenesis
activates Wnt/β-catenin signaling pathway
involved in vascular development
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:RSPO1_gene
gptkb:RSPO2_gene
gptkb:RSPO4_gene
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:24666
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RSPO3 gene
|
|
gptkbp:interactsWith
|
gptkb:LGR4
gptkb:LGR5
gptkb:LGR6
|
|
gptkbp:length
|
8 exons
|
|
gptkbp:locatedOnChromosome
|
6
|
|
gptkbp:location
|
6q22.33
|
|
gptkbp:mutationAssociatedWith
|
can cause vascular malformations
can contribute to tumorigenesis
|
|
gptkbp:OMIM
|
610574
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Rspo3
|
|
gptkbp:product
|
R-spondin-3
|
|
gptkbp:regulates
|
gptkb:Wnt_signaling
|
|
gptkbp:UniProtID
|
Q9BXY4
|
|
gptkbp:bfsParent
|
gptkb:R-spondin_proteins
|
|
gptkbp:bfsLayer
|
7
|