|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
GPR49
LGR5 stem cell marker
Leucine-rich repeat-containing G-protein coupled receptor 5
|
|
gptkbp:associatedWith
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:biologicalProcess
|
cancer progression
cell signaling
receptor activity
organ development
epithelial cell differentiation
stem cell proliferation
|
|
gptkbp:chromosomeArm
|
12q21.1
|
|
gptkbp:discoveredBy
|
gptkb:Hans_Clevers
|
|
gptkbp:encodes
|
LGR5 protein
|
|
gptkbp:Entrez_Gene_ID
|
8549
ENSG00000139292
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
brain
liver
colon
stomach
hair follicle stem cells
intestinal stem cells
|
|
gptkbp:fullName
|
Leucine-rich repeat-containing G-protein coupled receptor 5
|
|
gptkbp:function
|
G-protein coupled receptor activity
stem cell marker
|
|
gptkbp:geneType
|
protein coding
|
|
gptkbp:hasTranscriptVariant
|
LGR5-201
LGR5-202
|
|
gptkbp:HGNC_ID
|
HGNC:13274
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LGR5
|
|
gptkbp:length
|
907
|
|
gptkbp:locatedOnChromosome
|
12
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
colorectal cancer
hepatocellular carcinoma
|
|
gptkbp:OMIM
|
606667
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
|
|
gptkbp:PDB
|
7VQH
|
|
gptkbp:proteinFamily
|
G-protein coupled receptor family
|
|
gptkbp:relatedTo
|
stem cell maintenance
tissue regeneration
tumorigenesis
|
|
gptkbp:target
|
gptkb:R-spondin_proteins
gptkb:Wnt_ligands
|
|
gptkbp:UniProtID
|
O75473
|
|
gptkbp:bfsParent
|
gptkb:R-spondin
gptkb:R-spondin_proteins
gptkb:TCF/LEF
|
|
gptkbp:bfsLayer
|
7
|