Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
Rho-associated, coiled-coil containing protein kinase 2
Rho-kinase 2 ROCK-II |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:cardiovascular_disease neurological disorders |
| gptkbp:discoveredIn |
1996
|
| gptkbp:encodes |
ROCK2 protein
|
| gptkbp:Entrez_Gene_ID |
9475
ENSG00000134318 |
| gptkbp:expressedIn |
widely expressed in human tissues
|
| gptkbp:fullName |
Rho-associated coiled-coil containing protein kinase 2
|
| gptkbp:function |
apoptosis
cell proliferation cell migration regulation of actin cytoskeleton smooth muscle contraction |
| gptkbp:HGNC_ID |
10251
|
| https://www.w3.org/2000/01/rdf-schema#label |
ROCK2 gene
|
| gptkbp:inhibitedBy |
gptkb:Y-27632
gptkb:fasudil |
| gptkbp:interactsWith |
gptkb:RhoA
gptkb:MYPT1 CITRON |
| gptkbp:length |
1388 amino acids
|
| gptkbp:locatedOnChromosome |
chromosome 2
2p24 |
| gptkbp:molecularWeight |
160 kDa
|
| gptkbp:mutationAssociatedWith |
implicated in hypertension
implicated in neurodegeneration implicated in tumor progression |
| gptkbp:OMIM |
601702
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
mouse Rock2 gene
rat Rock2 gene |
| gptkbp:pathway |
Rho signaling pathway
|
| gptkbp:phosphorylates |
gptkb:LIM_kinase
myosin light chain ERM proteins adducin |
| gptkbp:proteinFamily |
serine/threonine protein kinase
|
| gptkbp:regulates |
cell shape
cell adhesion cell motility myosin light chain phosphorylation |
| gptkbp:subcellularLocation |
gptkb:cell_membrane
gptkb:nucleus gptkb:cytoplasm |
| gptkbp:UniProtID |
O75116
|
| gptkbp:bfsParent |
gptkb:ROCK_(Rho-associated_kinase)
|
| gptkbp:bfsLayer |
7
|