MLKL

GPTKB entity

Statements (28)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy phosphorylation by RIPK3
gptkbp:amendedBy phosphorylation
gptkbp:associatedWith neurodegenerative diseases
inflammatory diseases
gptkbp:discoveredBy 2012
gptkbp:encodedBy MLKL gene
gptkbp:Entrez_Gene_ID 197259
gptkbp:fullName Mixed lineage kinase domain-like protein
gptkbp:function mediates necroptosis
https://www.w3.org/2000/01/rdf-schema#label MLKL
gptkbp:interactsWith gptkb:RIPK3
phosphatidylinositol phosphates
gptkbp:involvedIn programmed cell death
inflammatory response
gptkbp:length 471 amino acids
gptkbp:locale gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:locatedOnChromosome 16q23.1
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Danio_rerio
gptkb:Mus_musculus
gptkbp:PDB 4MWI
gptkbp:structure contains pseudokinase domain
contains four-helix bundle domain
gptkbp:UniProtID gptkb:Q8NB16
gptkbp:bfsParent gptkb:MLNK
gptkbp:bfsLayer 7