Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
phosphorylation by RIPK3
|
| gptkbp:amendedBy |
phosphorylation
|
| gptkbp:associatedWith |
neurodegenerative diseases
inflammatory diseases |
| gptkbp:discoveredBy |
2012
|
| gptkbp:encodedBy |
MLKL gene
|
| gptkbp:Entrez_Gene_ID |
197259
|
| gptkbp:fullName |
Mixed lineage kinase domain-like protein
|
| gptkbp:function |
mediates necroptosis
|
| gptkbp:interactsWith |
gptkb:RIPK3
phosphatidylinositol phosphates |
| gptkbp:involvedIn |
programmed cell death
inflammatory response |
| gptkbp:length |
471 amino acids
|
| gptkbp:locale |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:locatedOnChromosome |
16q23.1
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
gptkb:Danio_rerio
gptkb:Mus_musculus |
| gptkbp:PDB |
4MWI
|
| gptkbp:structure |
contains pseudokinase domain
contains four-helix bundle domain |
| gptkbp:UniProtID |
gptkb:Q8NB16
|
| gptkbp:bfsParent |
gptkb:MLNK
gptkb:RIPK3 gptkb:RIPK1 |
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
MLKL
|