RET receptor tyrosine kinase

URI: https://gptkb.org/entity/RET_receptor_tyrosine_kinase

GPTKB entity

Statements (48)

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:alias	gptkb:RET_proto-oncogene Proto-oncogene c-RET
gptkbp:alternativeSplicing	produces multiple isoforms
gptkbp:associatedWith	gptkb:Hirschsprung's_disease gptkb:medullary_thyroid_carcinoma gptkb:multiple_endocrine_neoplasia_type_2
gptkbp:biologicalProcess	protein tyrosine kinase activity
gptkbp:discoveredBy	gptkb:Yoshiki_Takahashi
gptkbp:discoveredIn	1985
gptkbp:encodedBy	gptkb:RET_gene
gptkbp:Entrez_Gene_ID	5979 ENSG00000165731
gptkbp:expressedIn	gptkb:kidney thyroid gland neural crest-derived cells
gptkbp:formsComplexWith	GFRα co-receptors
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	cell signaling regulation of cell differentiation regulation of cell growth
gptkbp:GO	GO:0005003
gptkbp:HGNC_ID	9967
https://www.w3.org/2000/01/rdf-schema#label	RET receptor tyrosine kinase
gptkbp:ligand	GDNF family ligands
gptkbp:locatedOnChromosome	gptkb:chromosome_10q11.2
gptkbp:membraneLocation	gptkb:plasma_membrane
gptkbp:molecularWeight	~120 kDa
gptkbp:mutationAssociatedWith	gain-of-function loss-of-function
gptkbp:OMIM	164761
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:pathway	gptkb:MAPK_signaling_pathway gptkb:PI3K-Akt_signaling_pathway gptkb:neurotrophin_signaling_pathway
gptkbp:PDB	6I83 6Q2J 6Q2N
gptkbp:phosphorylates	tyrosine residues autophosphorylation upon ligand binding
gptkbp:structure	extracellular domain, transmembrane domain, intracellular tyrosine kinase domain
gptkbp:target	gptkb:pralsetinib gptkb:selpercatinib
gptkbp:UniProtID	P07949
gptkbp:bfsParent	gptkb:RET_proto-oncogene
gptkbp:bfsLayer	5