Protein tyrosine kinase 2 beta

URI: https://gptkb.org/entity/Protein_tyrosine_kinase_2_beta
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:PTK2B
gptkb:FAK2
gptkb:PYK2
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:cancer
gptkbp:biologicalProcess cell proliferation
cell migration
ATP binding
protein kinase activity
regulation of cytoskeleton organization
gptkbp:discoveredBy Lev S. Tatarinov
gptkbp:discoveredIn 1995
gptkbp:domain gptkb:FAT_domain
kinase domain
FERM domain
gptkbp:encodedBy PTK2B gene
gptkbp:Entrez_Gene_ID 2185
gptkbp:enzymeCommissionNumber 2.7.10.2
gptkbp:family focal adhesion kinase family
gptkbp:function signal transduction
non-receptor protein tyrosine kinase
https://www.w3.org/2000/01/rdf-schema#label Protein tyrosine kinase 2 beta
gptkbp:interactsWith gptkb:SRC
gptkb:GRB2
gptkb:STAT3
p130Cas
gptkbp:length 1009 amino acids
gptkbp:locatedOnChromosome gptkb:8p21.2
gptkbp:location gptkb:cytoplasm
focal adhesions
gptkbp:molecularWeight 116 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Ptk2b
gptkbp:PDB 2A07
3FZR
4EKU
gptkbp:phosphorylates Tyr402
Tyr579
Tyr580
Tyr881
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:RefSeq NP_004100.2
gptkbp:UniProtID gptkb:Q14289
gptkbp:bfsParent gptkb:PTK2B
gptkbp:bfsLayer 8