Polycomb Repressive Complex 1

URI: https://gptkb.org/entity/Polycomb_Repressive_Complex_1
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:PRC1
gptkbp:alternativeName gptkb:PRC1_complex
gptkbp:amendedBy gptkb:histone_H2A
gptkbp:biologicalProcess cell differentiation
development
epigenetic regulation
gptkbp:catalyzes gptkb:ubiquitin_ligase
gptkbp:component gptkb:PCGF_proteins
gptkb:CBX_proteins
gptkb:PHC_proteins
gptkb:RING1A
gptkb:RING1B
BMI1
gptkbp:conservedIn animals
plants
gptkbp:discoveredBy gptkb:Drosophila_melanogaster
gptkbp:function gene silencing
chromatin modification
gptkbp:GO_term GO:0035102
https://www.w3.org/2000/01/rdf-schema#label Polycomb Repressive Complex 1
gptkbp:involves gptkb:X-chromosome_inactivation
cancer progression
stem cell maintenance
gptkbp:locale gptkb:nucleus
gptkbp:modification_site lysine 119 of histone H2A
gptkbp:modification_type monoubiquitination
gptkbp:regulates gptkb:Hox_gene_clusters
gptkbp:relatedTo gptkb:Polycomb_Repressive_Complex_2
gptkb:Polycomb_group_proteins
gptkbp:UniProtID Q9H9B1 (RING1B)
gptkbp:bfsParent gptkb:Polycomb-group_proteins
gptkbp:bfsLayer 7