Polycomb Repressive Complex 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:PRC1
gptkbp:alternativeName	gptkb:PRC1_complex
gptkbp:amendedBy	gptkb:histone_H2A
gptkbp:biologicalProcess	cell differentiation development epigenetic regulation
gptkbp:catalyzes	gptkb:ubiquitin_ligase
gptkbp:component	gptkb:PCGF_proteins gptkb:CBX_proteins gptkb:PHC_proteins gptkb:RING1A gptkb:RING1B BMI1
gptkbp:conservedIn	animals plants
gptkbp:discoveredBy	gptkb:Drosophila_melanogaster
gptkbp:function	gene silencing chromatin modification
gptkbp:GO_term	GO:0035102
gptkbp:involves	gptkb:X-chromosome_inactivation cancer progression stem cell maintenance
gptkbp:locale	gptkb:nucleus
gptkbp:modification_site	lysine 119 of histone H2A
gptkbp:modification_type	monoubiquitination
gptkbp:regulates	gptkb:Hox_gene_clusters
gptkbp:relatedTo	gptkb:Polycomb_Repressive_Complex_2 gptkb:Polycomb_group_proteins
gptkbp:UniProtID	Q9H9B1 (RING1B)
gptkbp:bfsParent	gptkb:Polycomb-group_proteins
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Polycomb Repressive Complex 1