Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:MDR1
gptkb:P-glycoprotein_1 |
| gptkbp:discoveredIn |
1976
|
| gptkbp:encodedBy |
gptkb:ABCB1_gene
|
| gptkbp:expressedIn |
gptkb:kidney
gptkb:blood-brain_barrier liver intestine |
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
ATP-dependent drug efflux pump
|
| https://www.w3.org/2000/01/rdf-schema#label |
Pgp-1
|
| gptkbp:involvedIn |
multidrug resistance
|
| gptkbp:locatedIn |
gptkb:cell_membrane
|
| gptkbp:locatedOnChromosome |
chromosome 7q21.12
|
| gptkbp:memberOf |
gptkb:ATP-binding_cassette_transporter_family
|
| gptkbp:role |
protects tissues from toxic substances
|
| gptkbp:significance |
associated with chemotherapy resistance
impacts drug absorption and distribution |
| gptkbp:substrate |
antibiotics
antiviral drugs anticancer drugs immunosuppressants |
| gptkbp:UniProtID |
P08183
|
| gptkbp:bfsParent |
gptkb:CD44
|
| gptkbp:bfsLayer |
7
|