|
gptkbp:instanceOf
|
gptkb:protein
transmembrane transporter
|
|
gptkbp:alternativeName
|
gptkb:MDR1
ATP-binding cassette sub-family B member 1
|
|
gptkbp:associatedWith
|
chemotherapy resistance
pharmacokinetics of drugs
|
|
gptkbp:discoveredBy
|
gptkb:Victor_Ling
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:encodedBy
|
gptkb:ABCB1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5243
ENSG00000085563
|
|
gptkbp:expressedIn
|
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:blood-brain_barrier
liver
intestine
|
|
gptkbp:foundIn
|
gptkb:cell_membrane
|
|
gptkbp:function
|
multidrug resistance
drug efflux transporter
|
|
gptkbp:hasPolymorphism
|
C1236T
C3435T
G2677T/A
|
|
gptkbp:HGNC_ID
|
HGNC:40
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P-glycoprotein 1
|
|
gptkbp:inhibitedBy
|
gptkb:tariquidar
gptkb:verapamil
cyclosporin A
|
|
gptkbp:locatedOnChromosome
|
chromosome 7q21.12
|
|
gptkbp:memberOf
|
gptkb:ATP-binding_cassette_(ABC)_transporter_family
|
|
gptkbp:molecularWeight
|
~170 kDa
|
|
gptkbp:OMIM
|
171050
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:role
|
gptkb:blood-brain_barrier
renal excretion
intestinal absorption
hepatic clearance
|
|
gptkbp:significance
|
influences drug response
affects drug toxicity
implicated in HIV drug resistance
implicated in epilepsy drug resistance
|
|
gptkbp:structure
|
two homologous halves, each with six transmembrane domains
|
|
gptkbp:substrate
|
antibiotics
antiviral drugs
anticancer drugs
immunosuppressive drugs
|
|
gptkbp:UniProtID
|
P08183
|
|
gptkbp:bfsParent
|
gptkb:Pgp-1
gptkb:P08138
|
|
gptkbp:bfsLayer
|
8
|