Peptidyl-prolyl cis-trans isomerase A

URI: https://gptkb.org/entity/Peptidyl-prolyl_cis-trans_isomerase_A
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alsoKnownAs gptkb:Cyclophilin_A
gptkb:PPIA
gptkbp:associatedWith gptkb:cancer
gptkb:cardiovascular_disease
HIV infection
gptkbp:biologicalProcess signal transduction
protein folding
immune response
gptkbp:EC_number 5.2.1.8
gptkbp:foundIn cytosol
extracellular exosomes
gptkbp:function protein folding
catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides
gptkbp:gene gptkb:PPIA_gene
https://www.w3.org/2000/01/rdf-schema#label Peptidyl-prolyl cis-trans isomerase A
gptkbp:inhibitedBy gptkb:Cyclosporin_A
gptkbp:interactsWith gptkb:HIV-1_capsid_protein
calcineurin
gptkbp:locatedOnChromosome chromosome 7p13
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight 18 kDa
gptkbp:OMIM 123840
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB gptkb:1AK4
1CWA
gptkbp:postTranslationalModification phosphorylation
acetylation
gptkbp:structure contains cyclophilin-type PPIase domain
gptkbp:UniProtID P62937
gptkbp:bfsParent gptkb:PPIase_A
gptkbp:bfsLayer 8