|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:VE-PTP
gptkb:HPTP_beta
gptkb:R-PTP-beta
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
vascular development
|
|
gptkbp:discoveredBy
|
Tonks et al.
|
|
gptkbp:domain
|
gptkb:protein_tyrosine_phosphatase_domain
immunoglobulin-like domain
fibronectin type III domain
|
|
gptkbp:encodes
|
gptkb:Receptor-type_tyrosine-protein_phosphatase_beta
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000138795
5787
|
|
gptkbp:expressedIn
|
endothelial cells
|
|
gptkbp:firstDescribed
|
1992
|
|
gptkbp:function
|
cell differentiation
cell growth regulation
protein tyrosine phosphatase activity
angiogenesis regulation
cell signaling regulation
|
|
gptkbp:geneType
|
protein coding
|
|
gptkbp:hasExtracellularDomain
|
yes
|
|
gptkbp:hasIntracellularDomain
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTPRB
|
|
gptkbp:interactsWith
|
gptkb:Ephrin_receptors
gptkb:Tie-2_receptor
gptkb:VE-cadherin
|
|
gptkbp:length
|
1981 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12q15-q21
|
|
gptkbp:molecularWeight
|
222 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:angiosarcoma
|
|
gptkbp:OMIM
|
600570
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ptprb
|
|
gptkbp:proteinFamily
|
gptkb:protein_tyrosine_phosphatase_family
receptor-type PTP family
|
|
gptkbp:regulates
|
cell migration
cell adhesion
blood vessel formation
endothelial cell junctions
vascular permeability
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:plasma_membrane
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P23467
|
|
gptkbp:bfsParent
|
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:bfsLayer
|
6
|