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gptkbp:instanceOf
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gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
CD202B
TEK receptor tyrosine kinase
|
|
gptkbp:binds
|
gptkb:angiopoietin-2
gptkb:angiopoietin-1
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:downstreamOf
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:encodedBy
|
gptkb:TEK_gene
|
|
gptkbp:expressedIn
|
vascular endothelium
|
|
gptkbp:foundIn
|
endothelial cells
|
|
gptkbp:function
|
regulation of angiogenesis
maintenance of blood vessel integrity
|
|
gptkbp:HGNC_ID
|
11742
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tie-2 receptor
|
|
gptkbp:involvedIn
|
tumor angiogenesis
vascular development
|
|
gptkbp:locatedOn
|
gptkb:chromosome_9q21
|
|
gptkbp:molecularWeight
|
approximately 145 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_hemorrhagic_telangiectasia
venous malformations
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
|
|
gptkbp:phosphorylates
|
activates downstream signaling pathways
|
|
gptkbp:structure
|
intracellular tyrosine kinase domain
extracellular immunoglobulin-like domains
|
|
gptkbp:target
|
therapeutic antibodies
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:Q02763
|
|
gptkbp:bfsParent
|
gptkb:PTPRB
|
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gptkbp:bfsLayer
|
7
|