|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
vascular endothelial cadherin
|
|
gptkbp:amendedBy
|
phosphorylation
endocytosis
|
|
gptkbp:antibodyAvailable
|
yes
|
|
gptkbp:discoveredBy
|
Takeichi lab
|
|
gptkbp:encodedBy
|
CDH5 gene
|
|
gptkbp:extracellularDomains
|
5
|
|
gptkbp:family
|
gptkb:cadherin_superfamily
|
|
gptkbp:firstDescribed
|
1990s
|
|
gptkbp:form
|
adherens junctions
|
|
gptkbp:foundIn
|
endothelial cells
|
|
gptkbp:function
|
cell adhesion
regulation of vascular permeability
maintenance of vascular integrity
|
|
gptkbp:gene
|
gptkb:CDH5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VE-cadherin
|
|
gptkbp:interactsWith
|
gptkb:alpha-catenin
gptkb:p120-catenin
gptkb:beta-catenin
|
|
gptkbp:locatedOnChromosome
|
16q22.1
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~130 kDa
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling
Notch signaling
VEGF signaling
|
|
gptkbp:regulates
|
phosphorylation
endocytosis
proteolytic cleavage
leukocyte transmigration
paracellular permeability
|
|
gptkbp:requires
|
embryonic vascular development
|
|
gptkbp:role
|
angiogenesis
tumor metastasis
blood vessel formation
endothelial cell junctions
|
|
gptkbp:significance
|
gptkb:cancer
sepsis
vascular diseases
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
transmembrane protein
|
|
gptkbp:target
|
inflammatory cytokines
VEGF signaling
|
|
gptkbp:UniProtID
|
P33151
|
|
gptkbp:bfsParent
|
gptkb:cadherins
gptkb:PTPRB
gptkb:cadherin_family
|
|
gptkbp:bfsLayer
|
7
|