Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:HCP
gptkb:PTPN6 gptkb:SHP-1 |
| gptkbp:discoveredBy |
Tonks et al.
|
| gptkbp:domain |
gptkb:protein_tyrosine_phosphatase_domain
SH2 domain |
| gptkbp:encodes |
gptkb:SHP-1
|
| gptkbp:Entrez_Gene_ID |
5777
ENSG00000060642 |
| gptkbp:expressedIn |
hematopoietic cells
|
| gptkbp:fullName |
protein tyrosine phosphatase, non-receptor type 1
|
| gptkbp:function |
negative regulation of cell signaling
dephosphorylation of phosphotyrosine residues |
| https://www.w3.org/2000/01/rdf-schema#label |
PTPNS1
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_12
gptkb:12p13 |
| gptkbp:mutationAssociatedWith |
leukemia
|
| gptkbp:OMIM |
176883
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
gptkb:Ptpn6
|
| gptkbp:proteinFamily |
gptkb:protein_tyrosine_phosphatase_family
|
| gptkbp:regulates |
gptkb:JAK/STAT_signaling_pathway
immune cell signaling |
| gptkbp:UniProtID |
gptkb:P29350
|
| gptkbp:bfsParent |
gptkb:PTPN10
|
| gptkbp:bfsLayer |
7
|