|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:PTP-H1
gptkb:PTPH1
|
|
gptkbp:alternativeName
|
gptkb:PTP-H1
gptkb:PTPH1
gptkb:Protein_tyrosine_phosphatase_H1
|
|
gptkbp:associatedWith
|
cancer (various types, research context)
|
|
gptkbp:domain
|
gptkb:protein_tyrosine_phosphatase_domain
PDZ domain
|
|
gptkbp:encodes
|
gptkb:Tyrosine-protein_phosphatase_non-receptor_type_3
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000119318
5774
|
|
gptkbp:enzymeClassification
|
EC 3.1.3.48
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
gptkb:testis
brain
liver
|
|
gptkbp:firstDescribed
|
1992
|
|
gptkbp:function
|
differentiation
signal transduction
cell growth regulation
protein tyrosine phosphatase activity
mitotic cycle regulation
|
|
gptkbp:gene
|
gptkb:PTPN3
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
9640
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTPN3
|
|
gptkbp:inhibitedBy
|
MAPK pathway (context-dependent)
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:p97/VCP
T-cell receptor signaling proteins
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9
9q31.3
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:OMIM
|
600243
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ptpn3
|
|
gptkbp:proteinFamily
|
gptkb:protein_tyrosine_phosphatase_family
|
|
gptkbp:RefSeq
|
gptkb:NM_002828
|
|
gptkbp:regulates
|
protein-protein interactions
cell signaling pathways
phosphorylation-dependent
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
membrane-associated
|
|
gptkbp:UniProtID
|
gptkb:P26045
|
|
gptkbp:bfsParent
|
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:bfsLayer
|
6
|