Ptpn2

GPTKB entity

Statements (27)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alias TC-PTP
gptkbp:associatedWith type 1 diabetes
autoimmune diseases
inflammatory bowel disease
gptkbp:biologicalProcess protein tyrosine phosphatase activity
JAK-STAT cascade regulation
cellular response to interferon-gamma
gptkbp:encodes protein tyrosine phosphatase, non-receptor type 2
gptkbp:Entrez_Gene_ID ENSMUSG00000021062
gptkbp:expressedIn gptkb:thymus
liver
spleen
hematopoietic cells
gptkbp:function negative regulation of cytokine signaling
regulation of immune response
dephosphorylation of tyrosine residues
https://www.w3.org/2000/01/rdf-schema#label Ptpn2
gptkbp:locatedOnChromosome mouse chromosome 18
gptkbp:MGI_ID MGI:97761
gptkbp:mutationAssociatedWith impaired immune function
increased susceptibility to colitis
gptkbp:organism gptkb:Mus_musculus
gptkbp:orthologIn PTPN2 (human)
gptkbp:UniProtID P17706
gptkbp:bfsParent gptkb:PTPN2
gptkbp:bfsLayer 7