|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:AMP
gptkb:ADP
|
|
gptkbp:alternativeName
|
gptkb:AMPK_alpha-1
gptkb:AMPK_catalytic_subunit_alpha-1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:type_2_diabetes
obesity
|
|
gptkbp:biologicalProcess
|
kinase activity
autophagy
cellular response to glucose starvation
regulation of fatty acid oxidation
regulation of glucose uptake
|
|
gptkbp:component
|
gptkb:AMP-activated_protein_kinase_(AMPK)_complex
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:AMP-activated_protein_kinase_catalytic_subunit_alpha-1
|
|
gptkbp:Entrez_Gene_ID
|
5562
ENSG00000132356
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
liver
adipose tissue
|
|
gptkbp:function
|
regulation of cellular energy homeostasis
phosphorylation of metabolic enzymes
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
NM_006251
NM_206907
|
|
gptkbp:HGNC_ID
|
9381
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PRKAA1 (human)
|
|
gptkbp:inhibitedBy
|
gptkb:ATP
|
|
gptkbp:interactsWith
|
gptkb:PRKAB1
gptkb:PRKAG1
gptkb:CAMKK2
STK11 (LKB1)
|
|
gptkbp:length
|
548
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5p13.1
|
|
gptkbp:molecularWeight
|
63 kDa
|
|
gptkbp:OMIM
|
602739
|
|
gptkbp:orthologInMouse
|
gptkb:Prkaa1
|
|
gptkbp:phosphorylates
|
gptkb:CaMKKβ
gptkb:LKB1
|
|
gptkbp:proteinFamily
|
serine/threonine protein kinases
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondrion
|
|
gptkbp:UniProtID
|
gptkb:Q13131
|
|
gptkbp:bfsParent
|
gptkb:Prkaa1
|
|
gptkbp:bfsLayer
|
8
|