|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
obesity
adrenal insufficiency
red hair phenotype
|
|
gptkbp:cleavage
|
prohormone convertases
|
|
gptkbp:discoveredBy
|
gptkb:Roger_Guillemin
|
|
gptkbp:encodes
|
pro-opiomelanocortin protein
|
|
gptkbp:Entrez_Gene_ID
|
5443
ENSG00000115138
|
|
gptkbp:expressedIn
|
gptkb:skin
gptkb:pituitary_gland
gptkb:placenta
embryonic development
hypothalamus
immune cells
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
gptkb:pro-opiomelanocortin
|
|
gptkbp:function
|
precursor polypeptide with multiple hormone activities
|
|
gptkbp:GO_Function
|
peptide hormone processing
hormone activity
melanocortin receptor binding
|
|
gptkbp:HGNC_ID
|
HGNC:9201
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
POMC
|
|
gptkbp:length
|
267 amino acids (human)
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
|
|
gptkbp:mutationAssociatedWith
|
adrenal insufficiency
early-onset obesity
red hair and pale skin
|
|
gptkbp:OMIM
|
176830
|
|
gptkbp:orthologInChicken
|
gptkb:POMC
|
|
gptkbp:orthologInDog
|
gptkb:POMC
|
|
gptkbp:orthologInMouse
|
Pomc
|
|
gptkbp:orthologInZebrafish
|
pomca
|
|
gptkbp:pathway
|
Adrenocorticotropic hormone synthesis
Melanocortin pathway
Opioid peptide biosynthesis
|
|
gptkbp:predecessor
|
gptkb:ACTH
gptkb:beta-endorphin
MSH
lipotropin
|
|
gptkbp:product
|
POMC protein
|
|
gptkbp:proteinFamily
|
prohormone
|
|
gptkbp:regulates
|
gptkb:insulin
gptkb:leptin
gptkb:corticotropin-releasing_hormone
|
|
gptkbp:UniProtID
|
P01189
|
|
gptkbp:bfsParent
|
gptkb:adrenocorticotropic_hormone
|
|
gptkbp:bfsLayer
|
7
|