corticotropin-releasing hormone

URI: https://gptkb.org/entity/corticotropin-releasing_hormone
GPTKB entity
Statements (36)
Predicate Object
gptkbp:instanceOf peptide
gptkbp:alternativeName gptkb:CRF
corticotropin-releasing factor
gptkbp:aminoAcidSequenceLength 41
gptkbp:CASNumber 86784-80-7
gptkbp:discoveredBy gptkb:Roger_Guillemin
gptkb:Wylie_Vale
gptkbp:discoveredIn 1981
gptkbp:encodedBy CRH gene
gptkbp:foundIn humans
mammals
gptkbp:function regulates immune response
regulates stress response
stimulates release of adrenocorticotropic hormone
gptkbp:halfLife less than 10 minutes
https://www.w3.org/2000/01/rdf-schema#label corticotropin-releasing hormone
gptkbp:medicalUse diagnosis of Cushing's syndrome
diagnosis of adrenal insufficiency
gptkbp:MeSH_ID D003418
gptkbp:predecessor prepro-CRH
gptkbp:producedBy gptkb:placenta
hypothalamus
peripheral tissues
gptkbp:PubChem_CID gptkb:CHEBI:28790
gptkbp:recipient CRH receptor 1
CRH receptor 2
gptkbp:relatedTo gptkb:hypothalamic-pituitary-adrenal_axis
gptkb:adrenocorticotropic_hormone
stress hormone
corticotropin
gptkbp:structure single-chain polypeptide
gptkbp:symbol gptkb:CRH
gptkbp:target anterior pituitary gland
gptkbp:UNII 4K5M5N8Q6D
gptkbp:bfsParent gptkb:CRH1
gptkbp:bfsLayer 6