|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:TRIM19
MYL
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:acute_promyelocytic_leukemia
|
|
gptkbp:component
|
nuclear body
|
|
gptkbp:degradationPathway
|
ubiquitin-proteasome system
|
|
gptkbp:discoveredBy
|
gptkb:Pier_Paolo_Pandolfi
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:domain
|
RING finger domain
B-box domain
coiled-coil domain
|
|
gptkbp:encodedBy
|
PML gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000140464
|
|
gptkbp:formsFusionGeneWith
|
RARA protein
|
|
gptkbp:fullName
|
Promyelocytic leukemia protein
|
|
gptkbp:function
|
tumor suppressor
regulation of apoptosis
regulation of cell proliferation
transcription regulation
protein binding
|
|
gptkbp:fusionProtein
|
gptkb:PML-RARA
|
|
gptkbp:GOProcess
|
cell cycle regulation
response to stress
|
|
gptkbp:hasIsoform
|
at least 7
|
|
gptkbp:HGNC_ID
|
9126
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PML protein
|
|
gptkbp:inhibitedBy
|
gptkb:arsenic_trioxide
|
|
gptkbp:interactsWith
|
gptkb:RB_protein
gptkb:p53_protein
SUMO proteins
|
|
gptkbp:locale
|
gptkb:nucleus
PML nuclear bodies
|
|
gptkbp:locatedOnChromosome
|
15q24
|
|
gptkbp:molecularWeight
|
~97 kDa (isoform 1)
|
|
gptkbp:mutationAssociatedWith
|
leads to leukemia
|
|
gptkbp:OMIM
|
102578
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
|
|
gptkbp:proteinFamily
|
TRIM family
|
|
gptkbp:RefSeq
|
NM_033238
|
|
gptkbp:regulates
|
cellular senescence
DNA damage response
p53 stability
|
|
gptkbp:structure
|
contains zinc finger motifs
|
|
gptkbp:targetOfDrug
|
gptkb:acute_promyelocytic_leukemia
|
|
gptkbp:UniProtID
|
P29590
|
|
gptkbp:bfsParent
|
gptkb:PML_(gene)
|
|
gptkbp:bfsLayer
|
7
|