|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:phosphatidylinositol_3,4,5-trisphosphate
phosphorylation
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes
|
|
gptkbp:cofactor
|
gptkb:ATP
|
|
gptkbp:compatibleWith
|
calcium
diacylglycerol
|
|
gptkbp:discoveredBy
|
gptkb:Yasutomi_Nishizuka
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.13
|
|
gptkbp:family
|
gptkb:protein_kinase_C_family
|
|
gptkbp:fullName
|
Protein kinase C zeta type
|
|
gptkbp:function
|
signal transduction
regulation of apoptosis
regulation of cell proliferation
regulation of cell polarity
|
|
gptkbp:gene
|
gptkb:PRKCZ
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PKCζ
|
|
gptkbp:inhibitedBy
|
gptkb:ICAP
aurothiomalate
|
|
gptkbp:interactsWith
|
gptkb:NF-κB_pathway
gptkb:PAR-3
gptkb:PAR-6
PARD6A
|
|
gptkbp:involvedIn
|
cell migration
immune response
insulin signaling
|
|
gptkbp:locale
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
1p36.33
|
|
gptkbp:molecularWeight
|
67 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1WMH
|
|
gptkbp:phosphorylates
|
Thr410
Thr560
|
|
gptkbp:regulates
|
cell differentiation
cell survival
gene expression
cytoskeletal organization
inflammatory response
|
|
gptkbp:subfamily
|
gptkb:atypical_protein_kinase_C
|
|
gptkbp:UniProtID
|
Q05513
|
|
gptkbp:bfsParent
|
gptkb:aPKC
gptkb:PKCzeta
gptkb:PAR6B
gptkb:PAR6C
|
|
gptkbp:bfsLayer
|
8
|