Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:PI3K-beta
p110-beta phosphoinositide-3-kinase beta catalytic subunit |
| gptkbp:associatedWith |
gptkb:cancer
insulin resistance |
| gptkbp:biologicalProcess |
cell proliferation
signal transduction cell migration kinase activity ATP binding apoptotic process phosphatidylinositol 3-kinase activity |
| gptkbp:cellularComponent |
gptkb:cell_membrane
gptkb:cytoplasm gptkb:plasma_membrane cytosol |
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000145675
5291 |
| gptkbp:expressedIn |
gptkb:skeletal_muscle
brain heart many tissues |
| gptkbp:fullName |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
|
| gptkbp:function |
involved in cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking
catalytic subunit of phosphoinositide 3-kinase (PI3K) beta isoform |
| gptkbp:gene |
gptkb:PIK3CB
|
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
8975
|
| https://www.w3.org/2000/01/rdf-schema#label |
PIK3CB (human)
|
| gptkbp:interactsWith |
gptkb:PIK3R1
gptkb:PIK3R2 G-protein beta-gamma subunits |
| gptkbp:length |
1070
|
| gptkbp:locatedOnChromosome |
3q22.3
|
| gptkbp:molecularWeight |
122 kDa
|
| gptkbp:OMIM |
602925
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
gptkb:Pik3cb
|
| gptkbp:pathway |
gptkb:PI3K-Akt_signaling_pathway
insulin signaling pathway |
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination |
| gptkbp:proteinFamily |
PI3/PI4-kinase family
|
| gptkbp:subunit |
heterodimer with regulatory subunit
binds to p85 regulatory subunit |
| gptkbp:UniProtID |
gptkb:P42338
|
| gptkbp:bfsParent |
gptkb:Pik3cb
|
| gptkbp:bfsLayer |
6
|